IL12RB1 抗体 (C-Term) (FITC)
Our Local Distributor
北京 101111
Quick Overview for IL12RB1 抗体 (C-Term) (FITC) (ABIN8001820)
抗原
See all IL12RB1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
原理
- Anti-IL12RB1 Antibody FITC Conjugated
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human IL12RB1.
-
亚型
- IgG
-
-
-
-
应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
-
有效期
- 12 months
-
-
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
-
别名
- IL12RB1
-
背景
-
Background: IL12RB1, mapped to 19p13.11, is also known as CD212. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. And this protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
Gene Full Name: interleukin 12 receptor subunit beta 1
-
基因ID
- 3594
-
UniProt
- P42701
-
途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
抗原
-