IRF4 抗体 (AA 163-419) (Biotin)
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Quick Overview for IRF4 抗体 (AA 163-419) (Biotin) (ABIN8001254)
抗原
See all IRF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 163-419
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原理
- Anti-MUM1/IRF4 Antibody Biotin Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MUM1/IRF4 recombinant protein (Position: A163-Q419). Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- IRF4 (Interferon Regulatory Factor 4 (IRF4))
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别名
- IRF4
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背景
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Background: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
Gene Full Name: interferon regulatory factor 4
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基因ID
- 3662
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UniProt
- Q15306
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途径
- Chromatin Binding
抗原
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