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HMMR 抗体 (C-Term) (Biotin)

The 兔 多克隆 anti-HMMR antibody is suitable to detect HMMR in samples from 人. It has been validated for WB, IHC 和 ELISA.
产品编号 ABIN7998499
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HMMR 抗体 (C-Term) (Biotin) (ABIN7998499)

抗原

See all HMMR 抗体
HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

适用

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宿主

  • 106
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克隆类型

  • 91
  • 21
多克隆

标记

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This HMMR antibody is conjugated to Biotin

应用范围

  • 72
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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 抗原表位

    • 20
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    C-Term

    原理

    Anti-CD168/HMMR Antibody Biotin Conjugated

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human CD168.

    亚型

    IgG
  • 应用备注

    Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

    有效期

    12 months
  • 抗原

    HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

    别名

    HMMR

    背景

    Background: HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.

    Gene Full Name: hyaluronan mediated motility receptor

    基因ID

    3161

    UniProt

    O75330

    途径

    Glycosaminoglycan Metabolic Process
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