GDF15 抗体 (AA 51-199) (PE)
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北京 101111
Quick Overview for GDF15 抗体 (AA 51-199) (PE) (ABIN7995314)
抗原
See all GDF15 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-199
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原理
- Anti-PDF Antibody PE Conjugated
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交叉反应 (详细)
- No cross reactivity with other proteins.
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预测反应
- Human PDF shares 82.4% amino acid (aa) sequence identity with mouse PDF.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PDF recombinant protein (Position: H51-Q199). Human PDF shares 82.4% amino acid (aa) sequence identity with mouse PDF.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- GDF15 (Growth Differentiation Factor 15 (GDF15))
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别名
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背景
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Background: Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.
Gene Full Name: peptide deformylase, mitochondrial
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基因ID
- 64146
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UniProt
- Q9HBH1
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途径
- SARS-CoV-2 Protein Interactome
抗原
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