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BCL6 抗体 (AA 501-600)

Name: BCL6 抗体 (AA 501-600)
SKU: ABIN749843
Availability: OutOfStock

This anti-BCL6 antibody is a 兔多克隆 antibody detecting BCL6 in WB, ELISA, IHC (p), IF (cc), IHC (fro) 和 IF (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 2+ publications.

Lane 1:mouse brain lysates probed with Rabbit Anti-Bcl6 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C. (BCL6 抗体 (AA 501-600))

Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Rabbit Anti BCL-6/5 Polyclonal Antibody, Unconjugated (ABIN749843) at 1:200 followed by conjugation to the secondary antibody and DAB staining (BCL6 抗体 (AA 501-600))

SDS

Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Rabbit Anti BCL-6/5 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (BCL6 抗体 (AA 501-600))

IHC (p)

Lane 1: mouse heart lysates Lane 2: mouse brain lysates probed with Anti BCL-6/5 Antibody, Unconjugated (ABIN749843) at 1:200 in 4 °C. (BCL6 抗体 (AA 501-600))

SDS

4 images

(2 references)

产品编号 ABIN749843

发货至: 中国

Quick Overview for BCL6 抗体 (AA 501-600) (ABIN749843)

抗原

See all BCL6 抗体

BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This BCL6 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

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AA 501-600

交叉反应

人, 小鼠

预测反应

Rat,Cow,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Bcl6

亚型

IgG
anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibody
BCL6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibody
BCL6 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal BCL6-1527 unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibody
BCL6 适用: 人, 小鼠 WB, IHC (p), IP, ChIP 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 147-276) antibody
BCL6 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 2G1B6 unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (Internal Region) antibody
BCL6 适用: 人, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 519-547) antibody
BCL6 适用: 人, 小鼠 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibody
BCL6 适用: 人 WB 宿主: 小鼠 Monoclonal BCL6-1475 unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 256-389) antibody
BCL6 适用: 人 IHC, ELISA, StM, Coat 宿主: 小鼠 Monoclonal BCL6-1982 unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (pSer333) antibody
BCL6 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 6 (BCL6) (AA 364-395) antibody
BCL6 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB43648 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Szabó, Gáspár, Dajnoki, Papp, Fábos, Szegedi, Zeher: "Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis." in: Immunology letters, Vol. 189, pp. 101-108, (2017) (PubMed).

Gong, Zhu, Pang, Ai, Gong, La, Ding: "Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5931-5941, (2017) (PubMed).
抗原

BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

别名

Bcl6

背景

Synonyms: BCL5, LAZ3, BCL6A, ZNF51, ZBTB27, B-cell lymphoma 6 protein, BCL-6, B-cell lymphoma 5 protein, BCL-5, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, BCL6
Background: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

基因ID

604

UniProt

P41182

途径

Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus