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GFRA1 抗体 (AA 25-227) (Fluoro647)

The 兔 多克隆 anti-GFRA1 antibody is suitable to detect GFRA1 in samples from 人. It has been validated for FACS.
产品编号 ABIN7993024
发货至: 中国
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Quick Overview for GFRA1 抗体 (AA 25-227) (Fluoro647) (ABIN7993024)

抗原

See all GFRA1 抗体
GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

适用

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宿主

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克隆类型

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多克隆

标记

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This GFRA1 antibody is conjugated to Fluoro647

应用范围

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Flow Cytometry (FACS)
  • 抗原表位

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    AA 25-227

    原理

    Anti-GDNF Receptor alpha 1/GFRA1 Antibody Fluoro647 Conjugated

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins

    预测反应

    Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse,rat GFRA1.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227). Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

    亚型

    IgG
  • 应用备注

    Flow Cytometry, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

    有效期

    12 months
  • 抗原

    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

    别名

    GFRA1

    背景

    Background: GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

    Gene Full Name: GDNF family receptor alpha 1

    Sequence Similarities: Belongs to the glutamate--cysteine ligase type 3 family.

    基因ID

    14585

    UniProt

    P56159
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