GFRA1 抗体 (AA 25-227) (Fluoro488)
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Quick Overview for GFRA1 抗体 (AA 25-227) (Fluoro488) (ABIN7993017)
抗原
See all GFRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-227
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原理
- Anti-GDNF Receptor alpha 1/GFRA1 Antibody Fluoro488 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse,rat GFRA1.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227). Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
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别名
- GFRA1
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背景
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Background: GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.
Gene Full Name: GDNF family receptor alpha 1
Sequence Similarities: Belongs to the glutamate--cysteine ligase type 3 family.
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基因ID
- 14585
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UniProt
- P56159
抗原
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