FOXM1 抗体 (AA 457-760) (Fluoro488)
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北京 101111
Quick Overview for FOXM1 抗体 (AA 457-760) (Fluoro488) (ABIN7991493)
抗原
See all FOXM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 457-760
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原理
- Anti-FOXM1 Antibody Fluoro488 Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human FOXM1 recombinant protein (Position: Q457-P760).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- FOXM1 (Forkhead Box M1 (FOXM1))
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别名
- FOXM1
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背景
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Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 brain washes normal cells to adopt cancer-like epigenome.
Gene Full Name: forkhead box M1
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基因ID
- 2305
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UniProt
- Q08050
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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