ERN1 抗体 (AA 158-280) (Fluoro550)
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Quick Overview for ERN1 抗体 (AA 158-280) (Fluoro550) (ABIN7987645)
抗原
See all ERN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 158-280
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原理
- Anti-IRE1/ERN1 Antibody Fluoro550 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human IRE1 recombinant protein (Position: R158-L280).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
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别名
- ERN1
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背景
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Background: The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene. This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Gene Full Name: endoplasmic reticulum to nucleus signaling 1
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基因ID
- 81
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UniProt
- O75460
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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