DLG4 抗体 (AA 18-711) (HRP)
Our Local Distributor
北京 101111
Quick Overview for DLG4 抗体 (AA 18-711) (HRP) (ABIN7985668)
抗原
See all DLG4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 18-711
-
原理
- Anti-PSD95/DLG4 Antibody HRP Conjugated
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human PSD95/DLG4 recombinant protein (Position: D18-L711).
-
亚型
- IgG
-
-
-
-
应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))
-
别名
- DLG4
-
背景
-
Background: DLG4 discs large homolog 4, also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.
Gene Full Name: discs large MAGUK scaffold protein 4
-
基因ID
- 1742
-
UniProt
- P78352
-
途径
- Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
抗原
-