DOCK3 抗体 (AA 88-2006) (Biotin)
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北京 101111
Quick Overview for DOCK3 抗体 (AA 88-2006) (Biotin) (ABIN7984593)
抗原
See all DOCK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 88-2006
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原理
- Anti-MOCA/DOCK3 Antibody Biotin Conjugated
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- Human MOCA,DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA,DOCK3.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MOCA/DOCK3 recombinant protein (Position: E88-K2006). Human MOCA/DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA/DOCK3.
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亚型
- IgG
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anti-Dedicator of Cytokinesis 3 (DOCK3) (AA 1630-1934) antibody
DOCK3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))
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别名
- DOCK3
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背景
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Background: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.
Gene Full Name: dedicator of cytokinesis 3
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基因ID
- 1795
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UniProt
- Q8IZD9
抗原
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