Cullin 4B 抗体 (C-Term)
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Quick Overview for Cullin 4B 抗体 (C-Term) (ABIN7982053)
抗原
See all Cullin 4B (CUL4B) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- C-Term
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原理
- Anti-Cullin 4B/CUL4B Antibody
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- identical to the related rat,mouse sequences.
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产品特性
- Anti-Cullin 4B/CUL4B Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat, Zebrafish.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Cullin 4B, identical to the related rat and mouse sequences.
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亚型
- IgG
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anti-Cullin 4B (CUL4B) (AA 1-300) antibody
CUL4B 适用: 人, 小鼠, 犬 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-Cullin 4B (CUL4B) (Internal Region) antibodyCUL4B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 1-913) antibodyCUL4B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 250-278) antibodyCUL4B 适用: 人 WB 宿主: 兔 Polyclonal RB42521 unconjugated
anti-Cullin 4B (CUL4B) (AA 863-913) antibodyCUL4B 适用: 人, 小鼠 WB, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) antibodyCUL4B 适用: 人, 大鼠, 斑马鱼, 鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 1-300) antibodyCUL4B 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 小鼠 Monoclonal 7F8 unconjugated
anti-Cullin 4B (CUL4B) antibodyCUL4B 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (N-Term) antibodyCUL4B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 1-300) antibodyCUL4B 适用: 人 WB 宿主: 小鼠 Monoclonal 7G10 unconjugated
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应用备注
- Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, ZebrafishWestern blot, 0.1-0.5 μg/mL, Human, Rat, Zebrafish, Mouse
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Cullin 4B (CUL4B)
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别名
- CUL4B
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背景
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Background: Cullin 4B/CUL4B encodes a scaffold protein that organizes a cullin-RING (really interesting new gene) ubiquitin ligase (E3) complex in ubiquitylation. The CUL4 gene encodes a protein of 913 amino acids. The cullin domain is located between amino acid residues 217 and 815 and is characterized a by C-terminal globular domain (cullin homology domain) and a series of N-terminal repeats (cullin repeats). Ohtake et al. (2007) characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B (AhR). Complex assembly and ubiquitin ligase activity of CUL4B (AhR) in vitro and in vivo are dependent on the AhR ligand. In the CUL4B (AhR) complex, ligand-activated AhR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Their findings uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitin ligase complex.
Gene Full Name: cullin 4B
Sequence Similarities: Belongs to the cullin family.
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分子量
- 104 kDa
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基因ID
- 8450
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UniProt
- Q13620
抗原
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