CRYAA 抗体 (AA 1-173) (FITC)
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Quick Overview for CRYAA 抗体 (AA 1-173) (FITC) (ABIN7981915)
抗原
See all CRYAA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-173
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原理
- Anti-Alpha A Crystallin Antibody (monoclonal, 8H6) FITC Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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预测反应
- coli-derived human Alpha A Crystallin recombinant protein (Position: M1-S173). Human Alpha A Crystallin shares 94.8% amino acid (aa) sequence identity with both mouse,rat Alpha A Crystallin.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human Alpha A Crystallin recombinant protein (Position: M1-S173). Human Alpha A Crystallin shares 94.8% amino acid (aa) sequence identity with both mouse and rat Alpha A Crystallin.
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亚型
- IgG2b
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- CRYAA (Crystallin, alpha A (CRYAA))
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别名
- CRYAA
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背景
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Background: Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).
Gene Full Name: crystallin alpha A2
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基因ID
- 1409
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UniProt
- P02489
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途径
- M Phase
抗原
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