CRTC2 抗体 (C-Term) (Fluoro594)
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Quick Overview for CRTC2 抗体 (C-Term) (Fluoro594) (ABIN7981826)
抗原
See all CRTC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-TORC2/CRTC2 Antibody Fluoro594 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- different from the related rat sequence by three amino acids,and from the related mouse sequence by two amino acids.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human TORC2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
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别名
- CRTC2
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背景
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Background: CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene. This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
Gene Full Name: CREB regulated transcription coactivator 2
Sequence Similarities: Belongs to the TORC family.
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基因ID
- 200186
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UniProt
- Q53ET0
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途径
- AMPK Signaling, Carbohydrate Homeostasis
抗原
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