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CLOCK 抗体 (N-Term) (Fluoro488)

The Fluoro488-conjugated 兔 多克隆 anti-CLOCK antibody (ABIN7980557) specifically detects CLOCK in FACS. The antibody is reactive with 人, 小鼠, 大鼠 和 猴 samples.
产品编号 ABIN7980557
发货至: 中国
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Quick Overview for CLOCK 抗体 (N-Term) (Fluoro488) (ABIN7980557)

抗原

See all CLOCK 抗体
CLOCK (Clock Homolog (Mouse) (CLOCK))

适用

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人, 小鼠, 大鼠, 猴

宿主

  • 67
  • 6
  • 1
  • 1

克隆类型

  • 49
  • 26
多克隆

标记

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This CLOCK antibody is conjugated to Fluoro488

应用范围

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Flow Cytometry (FACS)
  • 抗原表位

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    N-Term

    原理

    Anti-KAT13D/CLOCK Antibody Fluoro488 Conjugated

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins

    预测反应

    different from the related mouse sequence by one amino acid,and identical to the related rat sequence.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the N-terminus of human KAT13D/CLOCK, different from the related mouse sequence by one amino acid, and identical to the related rat sequence.

    亚型

    IgG
  • 应用备注

    Flow Cytometry, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

    有效期

    12 months
  • 抗原

    CLOCK (Clock Homolog (Mouse) (CLOCK))

    别名

    CLOCK

    背景

    Background: Clock (Circadian Locomotor Output Cycles Kaput) is also known as KAT13D. The protein encoded by this gene plays a central role in the regulation of circadian rhythms. This protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. And the encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

    Gene Full Name: clock circadian regulator

    基因ID

    9575

    UniProt

    O15516

    途径

    Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
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