Claudin 18 抗体 (AA 31-261) (Fluoro594)
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北京 101111
Quick Overview for Claudin 18 抗体 (AA 31-261) (Fluoro594) (ABIN7980405)
抗原
See all Claudin 18 (CLDN18) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-261
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原理
- Anti-Claudin18/CLDN18 Antibody Fluoro594 Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Claudin18/CLDN18 recombinant protein (Position: S31-V261).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- Claudin 18 (CLDN18)
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别名
- CLDN18
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背景
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Background: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Full Name: claudin 18
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基因ID
- 51208
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UniProt
- P56856
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途径
- Cell-Cell Junction Organization, Hepatitis C
抗原
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