C9ORF72 抗体 (N-Term) (HRP)
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北京 101111
Quick Overview for C9ORF72 抗体 (N-Term) (HRP) (ABIN7980176)
抗原
See all C9ORF72 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-C9ORF72 Antibody HRP Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human C9ORF72, which shares 96.4% amino acid (aa) sequence identity with both mouse and rat C9ORF72.
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亚型
- IgG
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anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-230) antibody
C9ORF72 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 391-481) antibodyC9ORF72 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424), (C-Term) antibodyC9ORF72 适用: 人 WB 宿主: 兔 Polyclonal RB27382 unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 138-430) antibodyC9ORF72 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (N-Term) antibodyC9ORF72 适用: 人, 大鼠, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-481) antibodyC9ORF72 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
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别名
- C9ORF72
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背景
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Background: C9orf72 (chromosome 9 open reading frame 72) is a protein which in humans is encoded by the gene C9orf72. It is mapped to 9p21.2. The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Full Name: C9orf72-SMCR8 complex subunit
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基因ID
- 203228
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UniProt
- Q96LT7
抗原
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