C6orf150 抗体 (AA 352-504) (Biotin)
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北京 101111
Quick Overview for C6orf150 抗体 (AA 352-504) (Biotin) (ABIN7980137)
抗原
See all C6orf150 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 352-504
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原理
- Anti-cGAS Antibody Biotin Conjugated
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human cGAS recombinant protein (Position: A352-F504).
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anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 211-395) antibody
C6orf150 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 350-522) antibodyC6orf150 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 208-522) antibodyC6orf150 适用: 人 WB, IHC, ELISA, FACS, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 1-185) antibodyC6orf150 适用: 人 WB 宿主: 小鼠 Monoclonal 7E3 unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
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别名
- cGAS
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背景
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Background: cGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER). cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334). The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.
Gene Full Name: cyclic GMP-AMP synthase
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基因ID
- 214763
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UniProt
- Q8C6L5
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途径
- Activation of Innate immune Response
抗原
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