C4orf49 抗体 (AA 1-155) (Biotin)
Our Local Distributor
北京 101111
Quick Overview for C4orf49 抗体 (AA 1-155) (Biotin) (ABIN7980103)
抗原
See all C4orf49 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-155
-
原理
- Anti-MGARP Antibody Biotin Conjugated
-
预测反应
- Human C4orf49,MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49,MGARP.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.
-
亚型
- IgG
-
-
anti-Chromosome 4 Open Reading Frame 49 (C4orf49) (AA 176-204), (C-Term) antibody
C4orf49 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))
-
别名
- MGARP
-
背景
-
Background: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.
Gene Full Name: mitochondria localized glutamic acid rich protein
-
基因ID
- 84709
-
UniProt
- Q8TDB4
抗原
-
