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CLCN3 抗体 (AA 293-752) (Fluoro594)

This 兔 多克隆 antibody specifically detects CLCN3 in FACS. It exhibits reactivity toward 大鼠 和 人.
产品编号 ABIN7979535
发货至: 中国
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Quick Overview for CLCN3 抗体 (AA 293-752) (Fluoro594) (ABIN7979535)

抗原

See all CLCN3 抗体
CLCN3 (Chloride Channel 3 (CLCN3))

适用

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大鼠, 人

宿主

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克隆类型

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多克隆

标记

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This CLCN3 antibody is conjugated to Fluoro594

应用范围

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Flow Cytometry (FACS)
  • 抗原表位

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    AA 293-752

    原理

    Anti-CLCN3 Antibody Fluoro594 Conjugated

    预测反应

    Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human CLCN3 recombinant protein (Position: G293-R752). Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.

    亚型

    IgG
  • 应用备注

    Flow Cytometry, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

    有效期

    12 months
  • 抗原

    CLCN3 (Chloride Channel 3 (CLCN3))

    别名

    CLCN3

    背景

    Background: H+/Cl? exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene. This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

    Gene Full Name: chloride voltage-gated channel 3

    基因ID

    1182

    UniProt

    P51790
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