CCR10 抗体 (C-Term) (Biotin)
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北京 101111
Quick Overview for CCR10 抗体 (C-Term) (Biotin) (ABIN7978827)
抗原
See all CCR10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-GPR2/CCR10 Antibody Biotin Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- different from the related rat,mouse sequences by one amino acid.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human GPR2/CCR10, different from the related rat and mouse sequences by one amino acid.
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亚型
- IgG
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anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 1-52) antibody
CCR10 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 314-362) antibodyCCR10 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (C-Term) antibodyCCR10 适用: 人, 小鼠, 大鼠, 犬, Pig, Bat, Cow, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (Extracellular Domain) antibodyCCR10 适用: 人, 犬, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 9-31) antibodyCCR10 适用: 人 WB, ELISA, IHC, FACS, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (C-Term) antibodyCCR10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 1-30), (N-Term) antibodyCCR10 适用: 人 WB 宿主: 兔 Polyclonal RB33732 unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- CCR10 (Chemokine (C-C Motif) Receptor 10 (CCR10))
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别名
- CCR10
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背景
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Background: CCR10, C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. CCR10 is constitutively expressed in skin melanocytes, fibroblasts, and microvascular endothelial cells, and that it is upregulated by IL1B and TNF. Expression was also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in dendritic cells.By fluorescence in situ hybridization, the GPR2 gene is mapped to 17q21.1-q21.3. CCR10 is the receptor for CCL27. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, contact dermatitis, and psoriasis patients. CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients. Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes. CCR10 is predominantly expressed on CD4+CLA+ (cutaneous lymphocyte antigen), rather than CD8+, circulating T cells. RT-PCR, confocal microscopy, and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27.
Gene Full Name: C-C motif chemokine receptor 10
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
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基因ID
- 2826
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UniProt
- P46092
抗原
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