CDC6 抗体 (AA 147-549) (HRP)
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北京 101111
Quick Overview for CDC6 抗体 (AA 147-549) (HRP) (ABIN7977952)
抗原
See all CDC6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 147-549
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原理
- Anti-Cdc6 Antibody HRP Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human Cdc6 shares 87.3% amino acid (aa) sequence identity with mouse Cdc6.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Cdc6 recombinant protein (Position: V147-A549). Human Cdc6 shares 87.3% amino acid (aa) sequence identity with mouse Cdc6.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- CDC6 (Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6))
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别名
- CDC6
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背景
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Background: Cell division control ptotein 6 homolog, also called CDC18L or CDC6, is a protein that in humans is encoded by the CDC6 gene. By analysis of somatic cell hybrids and by fluorescence in situ hybridization, this gene is mapped to 17q21.2. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. And this protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. This gene is involved in the initiation of DNA replication.
Gene Full Name: cell division cycle 6
Sequence Similarities: Belongs to the CDC6/cdc18 family.
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基因ID
- 990
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UniProt
- Q99741
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途径
- DNA Replication, Synthesis of DNA
抗原
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