BUB1 抗体 (AA 731-1085) (HRP)
Our Local Distributor
北京 101111
Quick Overview for BUB1 抗体 (AA 731-1085) (HRP) (ABIN7973417)
抗原
See all BUB1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 731-1085
-
原理
- Anti-Bub1 AAMP Antibody HRP Conjugated
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 (详细)
- No cross-reactivity with other proteins
-
预测反应
- Human Bub1 shares 81% amino acid (aa) sequence identity with mouse Bub1.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human Bub1 recombinant protein (Position: V731-K1085). Human Bub1 shares 81% amino acid (aa) sequence identity with mouse Bub1.
-
亚型
- IgG
-
-
-
-
应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
-
别名
- BUB1
-
背景
-
Background: BUB1, also known as mitotic checkpoint serine/threonine kinase, is an enzyme that in humans is encoded by the BUB1 gene. It is mapped to 2q13. BUB1 is first identified in genetic screens of Saccharomyces cerevisiae. The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionary conserved in organisms as diverse as Saccharomyces cerevisiae and humans. Loss-of-function mutations or absence of BUB1 has been reported to result in aneuploidy, chromosomal instability (CIN) and premature senescence. The protein kinase BUB1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome alignment during metaphase.
Gene Full Name: BUB1 mitotic checkpoint serine/threonine kinase
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
-
基因ID
- 699
-
UniProt
- O43683
抗原
-