BCCIP 抗体 (AA 167-300)
Our Local Distributor
北京 101111
Quick Overview for BCCIP 抗体 (AA 167-300) (ABIN7973179)
抗原
See all BCCIP 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- AA 167-300
-
原理
- Anti-BCCIP Antibody
-
交叉反应 (详细)
- No cross reactivity with other proteins.
-
产品特性
- Anti-BCCIP Antibody. Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human BCCIP recombinant protein (Position: K167-K300).
-
亚型
- IgG
-
-
-
-
应用备注
- Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human ELISA, 0.1-0.5 μg/mL, -
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. -
有效期
- 12 months
-
-
- BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))
-
别名
- BCCIP
-
背景
-
Background: BRCA2 and CDKN1A-interacting protein is a protein that in humans is encoded by the BCCIP gene. This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Gene Full Name: BRCA2 and CDKN1A interacting protein
-
分子量
- 45 kDa
-
基因ID
- 56647
-
UniProt
- Q9P287
抗原
-