BAG2 抗体 (AA 1-211) (Biotin)
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Quick Overview for BAG2 抗体 (AA 1-211) (Biotin) (ABIN7972310)
抗原
See all BAG2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-211
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原理
- Anti-BAG2 Antibody Biotin Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- BAG2 (BCL2-Associated Athanogene 2 (BAG2))
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别名
- BAG2
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背景
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Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
Gene Full Name: BAG cochaperone 2
Sequence Similarities: Contains 1 P-type (trefoil) domain.
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基因ID
- 9532
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UniProt
- O95816
抗原
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