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B-Cell Linker 抗体 (AA 59-456) (Fluoro594)

The Fluoro594-conjugated 兔 多克隆 anti-B-Cell Linker antibody (ABIN7971938) specifically detects B-Cell Linker in FACS. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7971938
发货至: 中国
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Quick Overview for B-Cell Linker 抗体 (AA 59-456) (Fluoro594) (ABIN7971938)

抗原

See all B-Cell Linker (BLNK) 抗体
B-Cell Linker (BLNK)

适用

  • 128
  • 95
  • 66
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 137
  • 9
  • 1

克隆类型

  • 124
  • 23
多克隆

标记

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This B-Cell Linker antibody is conjugated to Fluoro594

应用范围

  • 127
  • 52
  • 38
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  • 16
  • 12
  • 7
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  • 3
  • 1
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Flow Cytometry (FACS)
  • 抗原表位

    • 26
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    • 9
    • 5
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    • 1
    AA 59-456

    原理

    Anti-BLNK Antibody Fluoro594 Conjugated

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human BLNK recombinant protein (Position: D59-S456).

    亚型

    IgG
  • 应用备注

    Flow Cytometry, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

    有效期

    12 months
  • 抗原

    B-Cell Linker (BLNK)

    别名

    BLNK

    背景

    Background: The B-cell linker protein is encoded by the BLNK gene and is an adaptor protein also known as SLP-65, BASH, and BCA. This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

    Gene Full Name: B cell linker

    基因ID

    29760

    UniProt

    Q8WV28

    途径

    BCR Signaling
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