ATR 抗体 (AA 24-1324) (Fluoro550)
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北京 101111
Quick Overview for ATR 抗体 (AA 24-1324) (Fluoro550) (ABIN7971496)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-1324
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原理
- Anti-ATR Antibody Fluoro550 Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ATR recombinant protein (Position: E24-D1324).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- ATR (ATR serine/threonine kinase (ATR))
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别名
- ATR
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背景
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Background: Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Gene Full Name: ATR checkpoint kinase
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基因ID
- 545
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UniProt
- Q13535
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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