ADC 抗体 (AA 1-448) (HRP)
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北京 101111
Quick Overview for ADC 抗体 (AA 1-448) (HRP) (ABIN7969989)
抗原
See all ADC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-448
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原理
- Anti-Arginine decarboxylase/AZIN2 Antibody HRP Conjugated
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human AZIN2 recombinant protein (Position: M1-L448).
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亚型
- IgG
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anti-Arginine Decarboxylase (ADC) (AA 1-448) antibody
ADC 适用: 人, 小鼠, 大鼠 WB, FACS, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 111-301) antibodyADC 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 51-150) antibodyADC 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Decarboxylase (ADC) (AA 179-228) antibodyADC 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- ADC (Arginine Decarboxylase (ADC))
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别名
- AZIN2
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背景
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Background: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
Gene Full Name: antizyme inhibitor 2
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基因ID
- 113451
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UniProt
- Q96A70
抗原
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