MST1 抗体 (AA 385-487) (Biotin)
Quick Overview for MST1 抗体 (AA 385-487) (Biotin) (ABIN747310)
抗原
See all MST1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 385-487
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MST1
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亚型
- IgG
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anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 385-487) antibody
MST1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 200-500) antibodyMST1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) antibodyMST1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 454-483) antibodyMST1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 489-716) antibodyMST1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (C-Term) antibodyMST1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 385-415), (C-Term) antibodyMST1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1193 unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 363-465) antibodyMST1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 540-589) antibodyMST1 适用: 人, 犬, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 1-711) antibodyMST1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))
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别名
- MST1
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背景
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Synonyms: KRS2, MST1, YSK3, TIIAC, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, STK4
Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
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基因ID
- 6789
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UniProt
- Q13043
抗原
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