AQP2 抗体 (AA 102-271) (Fluoro550)
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北京 101111
Quick Overview for AQP2 抗体 (AA 102-271) (Fluoro550) (ABIN7969667)
抗原
See all AQP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 102-271
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原理
- Anti-Aqp2 Antibody Fluoro550 Conjugated
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交叉反应 （详细）
- No cross reactivity with other proteins.
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预测反应
- Mouse Aqp2 shares 87.6%,98.2% amino acid (aa) sequence identity with human,rat Aqp2,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived mouse Aqp2 recombinant protein (Position: A102-A271). Mouse Aqp2 shares 87.6% and 98.2% amino acid (aa) sequence identity with human and rat Aqp2, respectively.
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亚型
- IgG
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anti-Aquaporin 2 (Collecting Duct) (AQP2) (AA 171-271) antibody
AQP2 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (C-Term) antibodyAQP2 适用: 人, 大鼠, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (AA 177-271) antibodyAQP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (AA 149-271) antibodyAQP2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7H8B5 unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (AA 147-271) antibodyAQP2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (C-Term) antibodyAQP2 适用: 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (AA 245-260) antibodyAQP2 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (AA 101-200) antibodyAQP2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (p), IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (pSer269) antibodyAQP2 适用: 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 2 (Collecting Duct) (AQP2) (C-Term) antibody (Atto 488)AQP2 适用: 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))
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别名
- Aqp2
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背景
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Background: AQP2 (Aquaporin 2), also called AQUAPORIN-CD, is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. The AQP2 gene is mapped to chromosome 12q13, very close to the site of major intrinsic protein by situ hybridization. The investigators suggested that a defect in the AQP2 gene is the basis of the autosomal form of nephrogenic diabetes insipidus. The functional expression and the limited localization suggested that AQP2 is the vasopressin-regulated water channel. Using rat kidney slices and porcine kidney cells stably expressing rat Aqp2, AQP2 trafficking can be stimulated by cAMP-independent pathways that utilize nitric oxide (NO). The NO donors sodium nitroprusside (SNP) and NONOate and the NO synthase substrate L-arginine mimicked the effect of vasopressin (VP), stimulating relocation of Aqp2 from cytoplasmic vesicles to the apical plasma membrane. SNP increased intracellular cGMP rather than cAMP, and exogenous cGMP stimulated AQP2 membrane insertion. Atrial natriuretic factor, which signals via cGMP, also stimulated AQP2 translocation. AQP2 expression in kidney connecting tubules is sufficient for survival and that AQP2 expression in collecting ducts is required to regulate body water balance. The S256L substitution in the cytoplasmic tail of the Aqp2 protein prevented phosphorylation at S256 and the subsequent accumulation of Aqp2 on the apical membrane of the collecting duct principal cells.
Gene Full Name: aquaporin 2
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基因ID
- 11827
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UniProt
- P56402
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途径
- Response to Water Deprivation
抗原
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