ASXL1 抗体 (AA 14-1541) (Fluoro647)
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北京 101111
Quick Overview for ASXL1 抗体 (AA 14-1541) (Fluoro647) (ABIN7966582)
抗原
See all ASXL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 14-1541
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原理
- Anti-ASXL1 Antibody Fluoro647 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ASXL1 recombinant protein (Position: A14-R1541).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- ASXL1 (Additional Sex Combs Like 1 (ASXL1))
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别名
- ASXL1
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背景
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Background: Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene. This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Gene Full Name: ASXL transcriptional regulator 1
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基因ID
- 171023
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UniProt
- Q8IXJ9
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途径
- Retinoic Acid Receptor Signaling Pathway
抗原
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