NT5DC3 抗体 (AA 52-548) (Fluoro550)
Our Local Distributor
北京 101111
Quick Overview for NT5DC3 抗体 (AA 52-548) (Fluoro550) (ABIN7965168)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 52-548
-
原理
- Anti-NT5DC3 Antibody Fluoro550 Conjugated
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human NT5DC3 recombinant protein (Position: D52-K548).
-
亚型
- IgG
-
-
anti-5'-Nucleotidase Domain Containing 3 (NT5DC3) (AA 437-486) antibody
NT5DC3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-5'-Nucleotidase Domain Containing 3 (NT5DC3) (AA 30-79) antibodyNT5DC3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-5'-Nucleotidase Domain Containing 3 (NT5DC3) (N-Term) antibodyNT5DC3 适用: 人, 小鼠, Cow, 犬, 大鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-5'-Nucleotidase Domain Containing 3 (NT5DC3) (C-Term) antibodyNT5DC3 适用: 人, 小鼠, Cow, 犬, 大鼠, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
-
有效期
- 12 months
-
-
- NT5DC3 (5'-Nucleotidase Domain Containing 3 (NT5DC3))
-
别名
- NT5DC3
-
背景
-
Background: 5'-Nucleotidase domain containing 2 (NT5DC2) is a member of the NT5DC family and contains a haloacid dehalogenase motif localized in the N-terminus of these proteins. NT5DC2 shows high sequence similarity with NT5C2. NT5C2 has received attention in the field of hematological neoplasms because NT5C2 mutations have been demonstrated to drive resistance to thiopurine, a drug frequently used to treat hematological neoplasms. NT5C2 catalyzes purine-nucleotide metabolism and induces chemotherapeutic resistance via excess export of purines to the extracellular space and depletion of the intracellular purine-nucleotide pool. Therefore, NT5DC2 may also participate in purine-nucleotide metabolism and exert purine-nucleotide catalytic activity. NT5DC2 overexpression promotes HCC cell proliferation and clone formation by regulating the cell cycle and promoting tumor growth in subcutaneous xenografts, while NT5DC2 knockdown inhibits these processes. NT5DC2 is associated with attention-deficit/hyperactivity disorder and bipolar disorder. NT5DC2 interacts with tyrosine hydroxylase (TH) to regulate TH catalytic activity and thus regulate catecholamine synthesis. NT5DC2 has been shown to interact with and stabilize Fyn, an Src family proto-oncogene, and plays a role in regulating glioblastoma progression.
Gene Full Name: 5'-nucleotidase domain containing 3
-
基因ID
- 51559
-
UniProt
- Q86UY8
抗原
-
