YTHDF2 抗体 (C-Term)
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Quick Overview for YTHDF2 抗体 (C-Term) (ABIN7938549)
抗原
See all YTHDF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- YTHDF2 antibody (pAb)
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纯化方法
- Affinity Purified
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免疫原
- This YTHDF2 antibody was raised against a fusion protein with His-tags at the C-terminus.
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亚型
- IgG
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anti-YTH Domain Family, Member 2 (YTHDF2) (N-Term) antibody
YTHDF2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Family, Member 2 (YTHDF2) (AA 201-500) antibodyYTHDF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-YTH Domain Family, Member 2 (YTHDF2) (AA 1-579) antibodyYTHDF2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-YTH Domain Family, Member 2 (YTHDF2) (AA 300-350) antibodyYTHDF2 适用: 人, 小鼠 WB, FACS 宿主: 兔 Monoclonal BLR297M unconjugated Recombinant Antibody
anti-YTH Domain Family, Member 2 (YTHDF2) (AA 300-350) antibodyYTHDF2 适用: 人, 小鼠 WB, FACS 宿主: 兔 Monoclonal BLR297M unconjugated Recombinant Antibody
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应用备注
- WB: 1 - 4 μg/mL
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS, 30 % glycerol, 0.035 % Azide. Sodium Azide is highly toxic.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))
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别名
- YTHDF2
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背景
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Background_Plain: YTHDF2 (YT521-B homology domain family 2, also known as CAHL, HGRG8, NY-REN-2) is a member of the YTH (YT521-B homology) superfamily containing YTH domain. Human YTH domain family proteins include three members, YTHDF1-3, which mainly localized in the cytoplasm. YTHDF proteins contain a highly conserved single-stranded RNA-binding domain which can specifically recognize and bind m6A-containing RNAs. An important role of YTHDF2is in regulating mRNA stability. YTHDF2 recognizes many m6A-containing mRNAs that are not being actively translated and recruits them to cytoplasmic processing (P) bodies for degradation. YTHDF2 preserves 5'UTR methylation of stress- induced transcripts and promotes cap-independent mRNA translation by competitive binding and limiting the m6A 'eraser' FTO from demethylation. N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs).
Aliases: YTH N6-Methyladenosine RNA Binding Protein 2, HGRG8
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分子量
- 70 kDa
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NCBI登录号
- NP_057342
抗原
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