SMC3 抗体 (acLys105, acLys106, C-Term)
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Quick Overview for SMC3 抗体 (acLys105, acLys106, C-Term) (ABIN7938499)
抗原
See all SMC3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- acLys105, acLys106, C-Term
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原理
- SMC3 K105acK106ac antibody (mAb)
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纯化方法
- Protein G Chromatography
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免疫原
- This SMC3 antibody was raised against a peptide in the C-terminal region of human SMC3.
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亚型
- IgG1
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应用备注
- WB*: 1:500 - 1:1,000 dilution The addition of 0.05 % Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. Individual optimization may be required.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS, 30 % glycerol, 0.035 % Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))
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别名
- SMC3
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背景
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Background_Plain: The Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression.SMC3 is a component of the cohesin complex that plays an essential role during chromatid segregation. SMC3 is also involved in DNA recombination and repair, mitotic chromosome organization and microtubule-mediated intracellular transport. SMC3 is acetylated during replication, which is essential for cohesion, and is phosphorylated by ATM after DNA double strand breakage. This antibody is acetylated at lysine 105/106.SMC3 is frequently elevated in human colon carcinoma and overexpression of the protein transforms fibroblasts.
Aliases: BAM, BMH, HCAP, CDLS3, CSPG6, SMC3L1
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分子量
- 141 kDa
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NCBI登录号
- NP_005436
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途径
- Stem Cell Maintenance
抗原
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