NAT10 抗体
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北京 101111
Quick Overview for NAT10 抗体 (ABIN7938364)
抗原
See all NAT10 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NAT10 antibody (pAb)
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纯化方法
- Protein A Chromatography
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免疫原
- This antibody was raised against a human RNA cytidine acetyltransferase isoform a.
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亚型
- IgG
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应用备注
- WB: 1 - 4 μg dilution
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限制
- 仅限研究用
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缓冲液
- Purified IgG supplied in 62 mM Trisodium citrate, 87 mM Tris pH 7, 30 % glycerol, 0.035 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))
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别名
- NAT10
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背景
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Background_Plain: NAT10 (N-Acetyltransferase 10) antibody is a RNA cytidine acetyltransferase that catalyzes the formation of N(4)- acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs and mediates the formation of ac4C at position 1842 in 18S rRNA. NAT10 requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, NAT10 is also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. It activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. NAT10 involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.
Aliases: N-Acetyltransferase 10
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分子量
- 130 kDa
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NCBI登录号
- NP_078938
抗原
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