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NAT10 抗体

This 兔 多克隆 antibody specifically detects NAT10 in WB. It exhibits reactivity toward 人.
产品编号 ABIN7938364
发货至: 中国
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Quick Overview for NAT10 抗体 (ABIN7938364)

抗原

See all NAT10 抗体
NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

适用

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宿主

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克隆类型

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多克隆

标记

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This NAT10 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 原理

    NAT10 antibody (pAb)

    纯化方法

    Protein A Chromatography

    免疫原

    This antibody was raised against a human RNA cytidine acetyltransferase isoform a.

    亚型

    IgG
  • 应用备注

    WB: 1 - 4 μg dilution

    限制

    仅限研究用
  • 缓冲液

    Purified IgG supplied in 62 mM Trisodium citrate, 87 mM Tris pH 7, 30 % glycerol, 0.035 % Sodium Azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

    储存条件

    -20 °C

    储存方法

    Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

    有效期

    24 months
  • 抗原

    NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

    别名

    NAT10

    背景

    Background_Plain: NAT10 (N-Acetyltransferase 10) antibody is a RNA cytidine acetyltransferase that catalyzes the formation of N(4)- acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs and mediates the formation of ac4C at position 1842 in 18S rRNA. NAT10 requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, NAT10 is also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. It activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. NAT10 involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.

    Aliases: N-Acetyltransferase 10

    分子量

    130 kDa

    NCBI登录号

    NP_078938
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