METTL14 抗体
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北京 101111
Quick Overview for METTL14 抗体 (ABIN7938342)
抗原
See all METTL14 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- METTL14 antibody (pAb)
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a human peptide containing methyltransferase 14.
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:2000 dilution IP: 4 µL per IP
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限制
- 仅限研究用
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缓冲液
- Purified in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- METTL14 (Methyltransferase Like 14 (METTL14))
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别名
- METTL14
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背景
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Background_Plain: N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs). METTL14 (methyltransferase-like 14)forms a stable N6-methyltransferase heterodimer complex with METTL3, which catalyzes the generation of m6A modification on mammalian nuclear RNAs. METTL3 is the catalytically active subunit, while METTL14 plays a structural role critical for substrate recognition.
Aliases: Methyltransferase Like 14, EC 2.1.1.62, N6-methyltransferase
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分子量
- 55kDa
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NCBI登录号
- NP_066012
抗原
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