METTL3 抗体 (N-Term)
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Quick Overview for METTL3 抗体 (N-Term) (ABIN7938336)
抗原
See all METTL3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- N-Term
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原理
- METTL3 antibody (mAb) (Clone 29C8)
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纯化方法
- Unpurified
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免疫原
- This antibody was raised against a peptide within the N-terminal region of human METTL3 (N6-adenosine-methyltransferase).
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亚型
- IgG2a
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anti-Methyltransferase Like 3 (METTL3) antibody
METTL3 适用: 人, 大鼠, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) (AA 1-156) antibodyMETTL3 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) (C-Term) antibodyMETTL3 适用: 人 WB, IHC, IF, ELISA, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) (AA 1-580) antibodyMETTL3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) antibodyMETTL3 适用: 人 WB, FACS, ICC, IF (p) 宿主: 兔 Monoclonal 24GB475 unconjugated Recombinant Antibody
anti-Methyltransferase Like 3 (METTL3) (N-Term) antibodyMETTL3 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 马, 豚鼠, 兔, Cow, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) (AA 1-50) antibodyMETTL3 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) (AA 1-50) antibodyMETTL3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) (C-Term) antibodyMETTL3 适用: 人, 大鼠, 小鼠, 犬, 斑马鱼, 马, 豚鼠, 兔, Cow, 山羊, Pig, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 3 (METTL3) antibodyMETTL3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500 - 1:1000 dilution This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91333.
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限制
- 仅限研究用
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缓冲液
- This antibody is provided as a hybridoma culture supernatant with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- METTL3 (Methyltransferase Like 3 (METTL3))
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别名
- METTL3
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背景
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Background_Plain: N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also occurs in other RNA molecules, such as primary miRNA (pri-miRNAs). METTL3 (methyltransferase-like 3, also known as IME4, M6A, MT-A70) forms a stable N6-methyltransferase heterodimer complex with METTL14, which catalyzes the generation of m6A modification on mammalian nuclear RNAs. METTL3 is the catalytically active subunit, while METTL14 plays a structural role critical for substrate recognition. METTL3 promotes translation by interacting with the translation initiation machinery in the cytoplasm. Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation.
Aliases: Methyltransferase Like 3, MRNA (2-O-Methyladenosine-N(6)-)-Methyltransferase
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分子量
- 72 kDa
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NCBI登录号
- NP_062826
抗原
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