CRTC2 抗体 (pSer171) (FITC)
Quick Overview for CRTC2 抗体 (pSer171) (FITC) (ABIN745995)
抗原
See all CRTC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer171
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Dog,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171
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亚型
- IgG
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应用备注
- FCM 1:20-100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
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别名
- TORC2
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背景
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Synonyms: TORC2, TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, CRTC2
Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
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基因ID
- 200186
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UniProt
- Q53ET0
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途径
- AMPK Signaling, Carbohydrate Homeostasis
抗原
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