CRTC2 抗体 (pSer171)
(4 references)Our Local Distributor
北京 101111
Quick Overview for CRTC2 抗体 (pSer171) (ABIN745988)
抗原
See all CRTC2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer171
-
交叉反应
- 人, 小鼠
-
预测反应
- Rat,Dog,Pig
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171
-
亚型
- IgG
-
-
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (C-Term) antibody
Verified CRTC2 适用: 人, 大鼠 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibodyCRTC2 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5B10 unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) antibodyKD Validated CRTC2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB250 unconjugated Recombinant Antibody
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 595-693) antibodyCRTC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E6 unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 180-372) antibodyCRTC2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 83-96) antibodyVerified CRTC2 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 542-553) antibodyVerified CRTC2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 595-693) antibodyCRTC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
-
: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." in: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).
: "Transcriptional regulation of autophagy by an FXR-CREB axis." in: Nature, Vol. 516, Issue 7529, pp. 108-11, (2015) (PubMed).
: "CRTC2 enhances HBV transcription and replication by inducing PGC1? expression." in: Virology journal, Vol. 11, Issue 1, pp. 30, (2014) (PubMed).
: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).
-
: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." in: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).
-
- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
-
别名
- TORC2
-
背景
-
Synonyms: TORC2, TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, CRTC2
Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
-
基因ID
- 200186
-
UniProt
- Q53ET0
-
途径
- AMPK Signaling, Carbohydrate Homeostasis
抗原
-
