我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

SATB1 抗体 (pSer47)

Name: SATB1 抗体 (pSer47)
SKU: ABIN745613
Availability: OutOfStock

This anti-SATB1 antibody is a 兔多克隆 antibody detecting SATB1 in ELISA, FACS, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人和小鼠. This Primary Antibody has been cited in 1 publication.

Formalin-fixed and paraffin embedded mouse spleen labeled with Rabbit Anti-SATB1 (Ser47) Polyclonal Antibody, Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining (SATB1 抗体 (pSer47))

IHC (p)

1 image

(1 reference)

产品编号 ABIN745613

发货至: 中国

Datasheet as PDF

Quick Overview for SATB1 抗体 (pSer47) (ABIN745613)

抗原

See all SATB1 抗体

SATB1 (SATB Homeobox 1 (SATB1))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This SATB1 antibody is un-conjugated

应用范围

ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product SATB1 Primary Antibody

抗原表位
15

9

3

3

3

1

1

1

1

1

1

1

1

1
pSer47

交叉反应

人, 小鼠

预测反应

Dog,Cow,Pig,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human SATB1 around the phosphorylation site of Ser47

亚型

IgG
anti-SATB Homeobox 1 (SATB1) (AA 484-763) antibody
SATB1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (C-Term) antibody
SATB1 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (AA 671-764) antibody
SATB1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (AA 1-763) antibody
SATB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (Internal Region) antibody
Verified SATB1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) antibody
SATB1 适用: 人 ICC, DB 宿主: 小鼠 Monoclonal 3548D4_2a unconjugated

anti-SATB Homeobox 1 (SATB1) antibody
SATB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (AA 484-763) antibody
SATB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (AA 611-660) antibody
SATB1 适用: 人, 大鼠, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-SATB Homeobox 1 (SATB1) (N-Term) antibody
SATB1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Han, Xia, Qin, Han, Wu: "Phosphorylated SATB1 is associated with the progression and prognosis of glioma." in: Cell death & disease, Vol. 4, pp. e901, (2013) (PubMed).
抗原

SATB1 (SATB Homeobox 1 (SATB1))

别名

SATB1

背景

Synonyms: DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1, SATB1
Background: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

基因ID

6304

UniProt

Q01826

途径

Caspase Cascade in Apoptosis, Activated T Cell Proliferation