TMEM108 抗体 (Extracellular Loop)
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Quick Overview for TMEM108 抗体 (Extracellular Loop) (ABIN7885616)
抗原
See all TMEM108 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 208-223, Extracellular Loop
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原理
- A Rabbit Polyclonal Antibody to TMEM108 (Extracellular)
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预测反应
- Rat,mouse - 15 out of 16 amino acid residues identical.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GQKRPLGKIFQIYKGN, corresponding to amino acid residues 208 - 223 of human TMEM108
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亚型
- IgG
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anti-Transmembrane Protein 108 (TMEM108) (Middle Region) antibody
TMEM108 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 108 (TMEM108) (C-Term) antibodyTMEM108 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 108 (TMEM108) (AA 524-553), (C-Term) antibodyTMEM108 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB21272 unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- TMEM108 (Transmembrane Protein 108 (TMEM108))
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别名
- TMEM108
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背景
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Synonyms: Transmembrane Protein 108, Retrolinkin, RTLN
Description:
TMEM108 (Transmembrane Protein 108) is a transmembrane protein originally identified as Retrolinkin, a protein involved in retrograde axon transport in the brain.1
TMEM108 is predominantly expressed in the brain where it has roles in neural connectivity and plasticity.
Indeed, TMEM108 has garnered attention in neuropsychiatric research due to its involvement in several cellular processes critical for proper brain function. A growing body of evidence links TMEM108 dysregulation to a range of neuropsychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder (MDD).2,3
TMEM108 plays a role in dendritic spine formation and synaptic transmission in neurons. Abnormalities in these processes can disrupt neural circuitry, which is a common feature in neuropsychiatric conditions. Disrupted synaptic connectivity has been implicated in the cognitive and behavioral symptoms observed in disorders such as schizophrenia.4,5
Beyond neurons, TMEM108 is expressed in oligodendrocytes and their precursors. Impaired oligodendrocyte function and myelin integrity can affect signal propagation along axons, potentially contributing to the white matter abnormalities frequently reported in psychiatric disorders. This dual role in both neuronal and glial cells positions TMEM108 as a key factor in maintaining overall brain network integrity.6
Given its multifaceted role in brain physiology, TMEM108 is being investigated as a potential biomarker for early diagnosis and prognosis in neuropsychiatric disorders. Understanding its function could also pave the way for developing targeted therapies aimed at restoring synaptic and myelin integrity.
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基因ID
- 66000
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UniProt
- Q6UXF1
抗原
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