TACR1 抗体 (2nd Extracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for TACR1 抗体 (2nd Extracellular Loop) (ABIN7885566)
抗原
See all TACR1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- 2nd Extracellular Loop, AA 180-194
-
原理
- A Rabbit Polyclonal Antibody to Neurokinin 1 Receptor
-
预测反应
- Mouse - identical, human - 13,15 amino acid residues identical
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- CMIEWPEHPNRTYEK, corresponding to amino acid residues 180-194 of rat NK1 receptor
-
亚型
- IgG
-
-
anti-Tachykinin Receptor 1 (TACR1) (AA 2-50) antibody
TACR1 适用: 人, 大鼠 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (2nd Extracellular Loop), (AA 180-194) antibodyTACR1 适用: 大鼠 WB, IHC, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (2nd Extracellular Loop), (AA 180-194) antibody (Atto 488)KO Validated TACR1 适用: 大鼠 IHC, FACS, LCI 宿主: 兔 Polyclonal Atto 488
anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibodyVerified TACR1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (C-Term) antibodyTACR1 适用: 人, 大鼠, 豚鼠, 猴, 马, 兔, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (2nd Extracellular Loop), (AA 180-194) antibody (FITC)TACR1 适用: 大鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
anti-Tachykinin Receptor 1 (TACR1) (AA 140-243) antibodyTACR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibodyTACR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 1-29) antibodyTACR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Extracellular Domain) antibodyTACR1 适用: 人, 犬, 猴, Cow IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: 2.5 mg per reaction
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7237370)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW)
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存液
- Without preservative
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- TACR1 (Tachykinin Receptor 1 (TACR1))
-
别名
- NK1 receptor
-
背景
-
Synonyms: NK1 receptor, Tachykinin receptor 1, TACR1, Substance-P receptor, SPR
Description: Substance P (SP), Neurokinin A (NKA) and Neurokinin B (NKB) are all peptides belonging to the Tachykinin protein family. These three peptides, which demonstrate quite a heterogeneity in their distribution, exert their effect via three receptors: Neurokinin 1-3 receptors, members of the G-protein coupled receptor superfamily. However, Neurokinin 1 (NK1) receptor preferentially binds Substance P, Neurokinin 2 (NK2) receptor to NKA, and Neurokinin 3 (NK3) receptor to NKB1.Neurokinin receptors are distinguished by their seven transmembrane domains, an extracellular N-terminus and a cytosolic C-terminal. An unusual property of these receptors is the presence of introns as part of their structural organization1-3. Tachykinin receptors undergo alternative splicing. For example, NK1 receptor is detected with different C-terminal lengths. The longer receptor isoform is found in the brain whereas the truncated form is mostly detected in the periphery1,4.Due to the broad expression profile of tachykinin peptides, their respective receptors are also expressed in a similar fashion. NK1 receptor is widely expressed in neurons, endothelial cells, muscle and immune system cells. NK2 receptor is broadly expressed in the periphery and its expression in the brain is quite restricted. NK3 receptor on the other hand is largely expressed in the central nervous system and is also detected in the uterus, skeletal muscle, lung and liver1.Neurokinin receptors have been found in many pathophysiological indications and have therefore become targets for the development of pharmacological compounds. Such indications include cancer, psychological disorders, migraine and various inflammations, just to name a few5-8.
-
基因ID
- 24807
-
UniProt
- P14600
-
途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
抗原
-
