Synaptojanin 1 抗体 (Intracellular)
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北京 101111
Quick Overview for Synaptojanin 1 抗体 (Intracellular) (ABIN7885554)
抗原
See all Synaptojanin 1 (SYNJ1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1156-1171, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Synaptojanin 1
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预测反应
- Rat - identical. Human - 15 out of 16 amino acids identical.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EAPKSPGTARKDNIGR, corresponding to amino acid residues 1156 - 1171 of mouse SYNJ1
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亚型
- IgG
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anti-Synaptojanin 1 (SYNJ1) (AA 1030-1261) antibody
SYNJ1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 1 (SYNJ1) (N-Term) antibodySYNJ1 适用: 人, 大鼠, 小鼠, Pig, 犬, 豚鼠, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 1474-1573) antibodySYNJ1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A2 unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 481-580) antibodySYNJ1 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (fro), ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 1148-1182), (C-Term) antibodySYNJ1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB53251 unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 1517-1551), (C-Term) antibodySYNJ1 适用: 人 WB 宿主: 兔 Polyclonal RB52973 unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 1474-1573) antibodySYNJ1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Synaptojanin 1 (SYNJ1) (N-Term) antibodySYNJ1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 100-200) antibodySYNJ1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Synaptojanin 1 (SYNJ1) (AA 1190-1239) antibodySYNJ1 适用: 人, Pig, 犬, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Synaptojanin 1 (SYNJ1)
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别名
- SYNJ1
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背景
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Synonyms: Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1, INPP5G, PARK20, SYNJ1
Description: Synaptojanin 1 (SYNJ1) is a phosphoinositide phosphatase primarily found in nerve terminals, where it plays a critical role in regulating synaptic vesicle recycling and neurotransmission, membrane trafficking and actin cytoskeleton dynamics. It belongs to the synaptojanin protein family, which includes other isoforms (SYNJ2 and SYNJ2BP) that also participate in cellular membrane dynamics and endocytic processes.1 Synaptojanin 1 is unique among phosphoinositide phosphatases in that it contains two catalytic domains that act on different substrates within the phosphoinositide signaling pathway. The SAC1 domain hydrolyzes phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 4-phosphate (PI4P), while the 5-phosphatase domain dephosphorylates phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) to PI4P and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P₃) to PI(3,4)P₂. 1,2 The coexistence of SAC1 and 5-phosphatase domains enables Synaptojanin 1 to orchestrate multiple steps in membrane trafficking across different subcellular compartments including vesicle uncoating, membrane trafficking, receptor recycling, and autophagy, processes fundamental to neuronal health, synaptic transmission, and plasticity.1,2,3 Based on its key function Synaptojanin 1 emerged as a key player in both short-term synaptic dynamics and long-term synaptic remodeling. In fact, Synaptojanin 1 dysfunction has been implicated in several neurodevelopmental and neurodegenerative disorders.3 Mutations in Synaptojanin 1 have been identified to result in comorbidities of early-onset Parkinsonism and epilepsy. The condition is now classified as PARK20, an autosomal recessive, juvenile-onset parkinsonism that presents with bradykinesia, dystonia, seizures, and cognitive impairment.3,4 Elevated levels of Synaptojanin 1, have been found in both human Alzheimer's disease (AD) brains, as well as mouse AD models and are correlated with cognitive decline linked to age.3,5
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基因ID
- 104015
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UniProt
- Q8CHC4
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途径
- Inositol Metabolic Process, Synaptic Vesicle Exocytosis
抗原
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