SYNDIG1 抗体 (Intracellular, N-Term)
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Quick Overview for SYNDIG1 抗体 (Intracellular, N-Term) (ABIN7885546)
抗原
See all SYNDIG1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 119-132, Intracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to SynDIG1
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSPTKDSLEYPDGK, corresponding to amino acid residues 119-132 of rat SynDIG1
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亚型
- IgG
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anti-Synapse Differentiation Inducing 1 (SYNDIG1) antibody
SYNDIG1 适用: 小鼠, 大鼠, 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Synapse Differentiation Inducing 1 (SYNDIG1) (AA 119-132), (Intracellular), (N-Term) antibodySYNDIG1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237303)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SYNDIG1 (Synapse Differentiation Inducing 1 (SYNDIG1))
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别名
- Synapse differentiation-inducing gene protein 1
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背景
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Synonyms: Synapse differentiation-inducing gene protein 1, Transmembrane Protein 90B, TMEM90B, Dispanin subfamily C member 2, DSPC2
Description: SynDIG1 (Synapse differentiation induced gene 1) is a brain-specific, highly conserved type II integral membrane protein detected at excitatory synapses. The protein is responsible for the regulation of excitatory synapse number and strength in hippocampal neurons. The protein plays an important role during synapse development in regulating AMPA receptor (AMPAR) and PSD-95 content at excitatory synapses1,2.SynDIG family includes four members: SynDIG1-4. SynDIG1 structure includes a large intracellular N-terminal region followed by a single transmembrane domain and a second hydrophobic segment that does not span the membrane. The membrane-associated region forms a three-helical bundle with two cysteine residues located at positions 191 and 192 in the juxta-transmembrane region exposed to the cytoplasm1,2.In studies conducted on mice, deletion of endogenous SynDIG1 in the mouse brain results in a significant decrease in excitatory synapse maturation, but not in synapse composition. Thus, SynDIG1 is not required for synaptogenesis in vivo1. Contrarily, overexpression of SynDIG1 in cultures of dissociated rat hippocampal neurons shows a significant increase in excitatory synapse strength and number.
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基因ID
- 362235
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UniProt
- Q58DZ9
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途径
- Synaptic Membrane
抗原
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