STOML1 抗体 (Extracellular, N-Term)
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Quick Overview for STOML1 抗体 (Extracellular, N-Term) (ABIN7885541)
抗原
See all STOML1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 4-17, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Stomatin-Like Protein 1
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预测反应
- Rat,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSGYRALPLGDFDR, corresponding to amino acid residues 4-17 of mouse STOML1
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亚型
- IgG
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anti-Stomatin (EPB72)-Like 1 (STOML1) antibody
STOML1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 1-398) antibodySTOML1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 107-206) antibodySTOML1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 79-290) antibodySTOML1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 1-30), (N-Term) antibodySTOML1 适用: 人 WB 宿主: 兔 Polyclonal RB37368 unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 4-17), (Extracellular), (N-Term) antibodySTOML1 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:500-1:800
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237284)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- STOML1 (Stomatin (EPB72)-Like 1 (STOML1))
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别名
- STOML1
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背景
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Synonyms: STOML1, SLP-1, STORP, Slipin-1, hUNC-24
Description: The Stomatin-like protein family contains five members and are characterized by the presence of a structurally conserved core called the stomatin-domain. This stomatin-domain is further related to a domain found in members of the prohibitin, flotillin and HflK/HflC protein families and has accordingly also been called the SPFH domain.All mammalian stomatin proteins are integral membrane protein with a single, relatively short, hydrophobic membrane insertion domain, followed by the core stomatin-domain. A single conserved proline residue (known to be a potent helix breaker) in the hydrophobic region is required for the formation of the protein's hairpin structure. The N-terminal domain is extracellular. Stomatin-like protein 1 (STOML1) has a typical stomatin-domain at the N-terminus and an additional sterol carrier protein-2 (SCP-2) domain at the C-terminus. STOML-1 is targeted to the late endosomal compartment where it interacts with stomatin. STOML-1 is predominantly expressed in the brain, in a subpopulation of sensory neurons in the dorsal root ganglia. Much lower levels are detected in other tissues1.Following anoxia, STOML-1 expression is up-regulated by the oxidative response factor SKN-1/Nrf. SKN-1/Nrf is required for both rapid mitochondrial refusion and rapid behavioral recovery during reoxygenation suggesting that STOML-1 helps facilitate mitochondrial dynamics following anoxia2.STOML-1 also modulates the proton-sensitive members of the acid-sensing ion channel (ASIC) family. STOML-1 strongly inhibits ASIC1a and accelerates the inactivation time constant of ASIC3, but has no effect on the splice variant ASIC1b3.
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基因ID
- 69106
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UniProt
- Q8CI66
抗原
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