Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) 抗体
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Quick Overview for Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) 抗体 (ABIN7885404)
抗原
适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1501-1518, Intracellular Loop
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原理
- A Rabbit Polyclonal Antibody to Pan NaV Channel
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预测反应
- The epitope is identical in all isoforms of NaV1 in all vertebrates,and highly homologous in molluscan,insect voltage-gated Na+ channels
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat NaV1.1
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亚型
- IgG
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anti-Sodium Channel-Pan (Internal Region), (pan) antibody
适用: 人, 小鼠, 大鼠 IF, IHC, WB, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Sodium Channel-Pan
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别名
- Pan sodium channel
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背景
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Synonyms: Pan sodium channel, SP19
Description: Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7
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基因ID
- 81574
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UniProt
- P04774
抗原
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