Serotonin Receptor 4 抗体 (2nd Extracellular Loop)
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Quick Overview for Serotonin Receptor 4 抗体 (2nd Extracellular Loop) (ABIN7885394)
抗原
See all Serotonin Receptor 4 (HTR4) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 2nd Extracellular Loop, AA 168-180
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 4
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预测反应
- Mouse - 12,13 amino acid residues identical, human - 11
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DVIEKRKFNHNSN, corresponding to amino acid residues 168-180 of rat 5-Hydroxytryptamine receptor 4
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亚型
- IgG
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anti-Serotonin Receptor 4 (HTR4) (AA 316-388) antibody
HTR4 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (Cytoplasmic Domain) antibodyHTR4 适用: 人, Cow, Pig, 犬, 马, 兔, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (2nd Extracellular Loop), (AA 168-180) antibodyKO Validated HTR4 适用: 大鼠 WB, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 21-120) antibodyHTR4 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (Middle Region) antibodyHTR4 适用: 人, 大鼠, 小鼠, Cow, Pig, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (N-Term) antibodyHTR4 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, Cow, 犬, 马, 豚鼠, 兔, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, Pig, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 144-193) antibodyHTR4 适用: 人, 大鼠, Cow, 犬, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 mg per reaction
ICC: 1:100
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Serotonin Receptor 4 (HTR4)
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别名
- 5-Hydroxytryptamine receptor 4
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背景
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Synonyms: 5-Hydroxytryptamine receptor 4, Serotonin receptor 4
Description: 5-hydroxytryptamine receptor 4 (5-HT4 receptors) are a subclass among the large family of receptors mediating serotonin actions at central and peripheral targets. 5-HT4 receptor activation has been implicated in learning and memory, feeding control and stress response. 5-HT4 receptors are encoded by a complex gene which in humans, generates ten different splice variants1, 2.The 5-HT4 receptor, a member of the seven transmembrane spanning G-protein-coupled receptors (GPCRs), couples via Gs to increase cAMP production. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs), the N-terminus is on the extracellular side of the membrane, and the C-terminus is on the cytoplasmic side3.Within the central nervous system, these receptors are expressed in limbic structures including: hypothalamus, nucleus accumbens, prefrontal cortex, amygdala and hippocampus, where they contribute to emotional and cognitive functions4.Low levels of 5-HT4 receptors are associated with numerous neuropsychiatric disorders including Alzheimer's disease, Huntington's disease, feeding disorders and stress-related disorders such as anxiety and depression5.
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基因ID
- 25324
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UniProt
- Q62758
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途径
- JAK/STAT Signaling, cAMP Metabolic Process, S100 Proteins
抗原
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