SCTR 抗体 (Extracellular, N-Term)
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Quick Overview for SCTR 抗体 (Extracellular, N-Term) (ABIN7885379)
抗原
See all SCTR 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 129-143, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Secretin Receptor
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预测反应
- 15 amino acid residues identical,Mouse - 14, human - 12
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- Peptide (C)NSFNERRHAYLLKLK, corresponding to amino acid residues 129 - 143 of rat Secretin Receptor
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亚型
- IgG
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anti-Secretin Receptor (SCTR) (AA 51-135) antibody
SCTR 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Secretin Receptor (SCTR) (AA 129-143), (Extracellular), (N-Term) antibodySCTR 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Secretin Receptor (SCTR) (AA 32-141) antibodySCTR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-Secretin Receptor (SCTR) (Internal Region) antibodySCTR 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Secretin Receptor (SCTR) (AA 188-280) antibodySCTR 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236749)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SCTR (Secretin Receptor (SCTR))
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别名
- SCTR
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背景
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Synonyms: SCTR
Description: Secretin receptor, SCTR, binds Secretin, a hormone that affects water homeostasis throughout the body and specifically in the duodenum of the small intestine.SCTR is ubiquitously expressed throughout the body. It belongs to class B1 of G-protein coupled receptors, along with vasoactive intestinal polypeptide (VIP) receptor. Like all G-protein coupled receptors, it is composed of seven highly conserved transmembrane domains1. The amino terminus of Secretin receptor plays a key role in agonist recognition and responsiveness2.The binding of SCTR to Secretin initiates a signaling cascade that stimulates bicarbonate secretion which in turn leads to neutralization of gastric H+. This process plays an essential role in fat digestion by creating a more neutral ( pH 6 to 8) environment. Secretin levels are regulated by H+ and fatty acids levels in the duodenum and hence the secretion regulation is tightly bound to its activity3.In addition, SCTR-Secretin interaction plays a major role in the regulation of the secretory activity in the heart, liver and the central nervous system (CNS)3.
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基因ID
- 6344
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UniProt
- P23811
抗原
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