RYR3 抗体 (Intracellular, N-Term)
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Quick Overview for RYR3 抗体 (Intracellular, N-Term) (ABIN7885376)
抗原
See all RYR3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 935-949, Intracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Ryanodine Receptor 3
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预测反应
- Rat,mouse - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CHIAHVNPAAEEDLK, corresponding to amino acid residues 935-949 of human RyR3
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亚型
- IgG
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anti-Ryanodine Receptor 3 (RYR3) (AA 987-1147) antibody
RYR3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 3 (RYR3) (AA 935-949), (Intracellular), (N-Term) antibodyRYR3 适用: 人 IHC, IF, WB, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236746)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- RYR3 (Ryanodine Receptor 3 (RYR3))
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别名
- RyR3
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背景
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Synonyms: RyR3, Brain-type ryanodine receptor
Description: It is well established that cytosolic calcium (Ca2+) acts as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The primary intracellular Ca2+ storage/release organelle in most cells is the endoplasmic reticulum (ER) or the sarcoplasmic reticulum (SR) in striated muscle cells.The ER and SR contain two Ca2+ release channel families, the inositol trisphosphate receptors (IP3Rs) and the ryanodine receptors (RyRs).3The ryanodine receptor family consists of three different isoforms: the skeletal muscle isoform, ryanodine receptor type 1 (RyR1), the cardiac muscle isoform, ryanodine receptor type 2 (RyR2) and the brain isoform, ryanodine receptor type 3 (RyR3).3The ryanodine receptors are homotetrameric proteins, which upon assembly create a Ca2+ conducting channel. They play a key role in the mechanism of excitation-contraction coupling in striated muscle. Binding of ryanodine (a poisonous alkaloid found in the South American plant Ryania speciosa) to the ryanodine receptor causes two major changes in the channel: a reduction in single-channel conductance and a marked increase in the open state probability, leading to an overall increase/decrease in the Ca2+ release capability of the channel.RyR3 is the most widely expressed RyR channel which is predominantly expressed in smooth muscle tissues and certain regions of the brain.
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基因ID
- 6263
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UniProt
- Q15413
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途径
- Myometrial Relaxation and Contraction
抗原
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