PLXNB1 抗体 (Extracellular, N-Term)
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Quick Overview for PLXNB1 抗体 (Extracellular, N-Term) (ABIN7885236)
抗原
See all PLXNB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1159-1174, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Plexin-B1 (extracellular)
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预测反应
- Human - identical. Rat - 13 out of 16 amino acid residues identical.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DPKVHSIFPARGPRAG, corresponding to amino acid residues 1159 - 1174 of mouse Plexin-B1
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亚型
- IgG
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anti-Plexin B1 (PLXNB1) (AA 200-727) antibody
PLXNB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plexin B1 (PLXNB1) (AA 1598-1849) antibodyPLXNB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plexin B1 (PLXNB1) (AA 664-837) antibodyPLXNB1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Plexin B1 (PLXNB1) (AA 151-250) antibodyPLXNB1 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Plexin B1 (PLXNB1) antibodyPLXNB1 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Plexin B1 (PLXNB1) (AA 1715-1749), (C-Term) antibodyPLXNB1 适用: 人 WB 宿主: 兔 Polyclonal RB52899 unconjugated
anti-Plexin B1 (PLXNB1) (AA 47-126) antibodyPLXNB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Plexin B1 (PLXNB1) (AA 1780-2042) antibodyPLXNB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- PLXNB1 (Plexin B1 (PLXNB1))
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别名
- PLXNB1
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背景
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Synonyms: Semaphorin receptor SEP, PLXNB1
Description:
Plexin-B1 is a transmembrane receptor that belongs to the plexin family, a group of proteins best known for their role in semaphorin signaling. As a receptor for Class IV semaphorins, particularly Semaphorin 4D (Sema4D) and Semaphorin 4A (Sema4A), Plexin-B1 regulates diverse biological functions including cytoskeletal remodeling, cell adhesion, and migration. Given this broad range of interactions, Plexin-B1 has become recognized as a critical regulator in neural development, immune response, and cancer biology.1
In the central nervous system, Plexin-B1 plays a pivotal role in axonal guidance and synapse formation. The receptor-ligand interactions with both Sema4D and Sema4A deliver directional signals that influence neural wiring. Notably, these ligands can provide either attractive or repulsive cues, depending on cellular context.1
Beyond its developmental functions, Plexin-B1 contributes to neuroinflammatory processes. In experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis, the Sema4D-Plexin-B1 interaction promotes microglial activation and the release of nitric oxide, exacerbating neuronal damage.2
Plexin-B1 is also widely expressed in the immune system, where it contributes to immune cell communication and migration. Both Sema4D and Sema4A are important ligands in this context. Sema4A, like Sema4D, is expressed on activated T cells and antigen-presenting cells. When it binds to Plexin-B1, it modulates T-cell activation and can influence cytokine production and immune tolerance. This dual-ligand functionality expands the scope of Plexin-B1's involvement in both innate and adaptive immune responses. Together, these interactions underscore Plexin-B1's central role in orchestrating immune dynamics and maintaining immune homeostasis.3,4
Aberrant Plexin-B1 expression and signaling are frequently observed in cancer, where they contribute to tumor progression and metastasis. Overexpression of Plexin-B1 has been documented in several cancers, including prostate, pancreatic, and skin carcinomas, often correlating with increased invasiveness and poor prognosis.5,6
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基因ID
- 235611
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UniProt
- Q8CJH3
抗原
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